Mathematics and the Genome

PPT Slide

Biology’s dilemma: There is too much to know about living things

Some important model organisms

Let’s find out everything about some species

Some genome sizes

Sequencing Genomes

How rough is the draft of the human genome?

Where to store all these data?

What’s in the databases?

First mathematical challenge:Sequencing large genomes

You have sequenced your genome - what do you do with it?

How the genome controls the organism

Where are the genes?

Hidden Markov Models for gene finding (caricature)

Hidden Markov Models for gene finding - the real picture

A big mathematical challenge

What did the Hidden Markov Models find?

So we know the genes - do we know everything?

From genes to proteins

Protein structure prediction

Prediction of gene function

Prediction of gene function: homology searches

Prediction of important sites in proteins

How to predict binding sites from sequence data:

Using genomic data for reconstruction of phylogenies

Methods for reconstruction of phylogenies

Reconstruction of phylogenies: A success story

Gene interactions: Collecting gene expression data

Gene interactions: Interpeting gene expression data

Interpeting gene expression data:A mathematical challenge

Gene expression profiles:A success story

The databases of the future

Email: just@math.ohiou.edu

Home Page: http://www.math.ohiou.edu/~just

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